The area-under-the diurnal plasma leptin curve did not change between CRC 1 and CRC 2 in either group [time: F(1,24) = 1.927, p = 0.178; time × group: F(1,24) = 0.594, p = 0.449 in RM-ANOVA], but decreased when subjects lost weight during the ad libitum period by 450 ± 896 arbitrary units (AU) in the control group, and by 350 ± 705 AU in the n-3-PUFA group [time: F(1,24) = 6.394, p = 0.018, time × group: F(1,24) = 0.100, p = 0.754 in RM-ANOVA; Figure 2]. Here, LEP is linked to colorectal carcinoma.