Our data also showed that the minor allele of CYP1B1 rs10175368 was significantly protective for adenocarcinoma of the lung (OR = 0.80, 95%CI = 0.69–0.93) and a similar protective effect was observed for the minor allele of CYP1B1 rs9341266 (r2 = 0.30), as well as for the cumulative sum of the two minor alleles. This evidence concerns the gene CYP1B1 and lung adenocarcinoma.