In adenocarcinoma cases only (test for heterogeneity by histology: pheterog = 0.066), the minor allele of CYP1B1 rs10175368 was significantly protective for lung cancer (OR = 0.8, 95%CI = 0.69–0.93, ptrend = 0.003) and a similar protective effect was nominally significant (i.e. p-value≤0.05) for the CYP1B1 rs9341266 polymorphism. The gene discussed is CYP1B1; the disease is adenocarcinoma.