The cumulative number of variants in CYP1B1 rs9341266 and CYP1B1 rs10175368 also conferred a significant protection for lung cancer in adenocarcinoma cases only (OR = 0.83, 95%CI = 0.74–0.94, ptrend = 0.002; test for heterogeneity by histology: pheterog = 0.058), in concordance with the two results from the single SNP analyses. This evidence concerns the gene CYP1B1 and lung cancer.