EPHX1 and lung cancer: Interestingly, the haplotype analysis for the 8 SNPs in EPHX1 (which were in low LD: r2≤0.1 for most SNPs pairs, r2 = 0.43 for EPHX1 rs2234922 and EPHX1 rs1051741) revealed two haplotypes significantly associated with lung cancer in the overall population: carriers of TGGCACTC haplotype had higher risk than non-carriers (freq = 0.01, p-value = 0.010) and carriers of CGGCGCCT haplotype had a lower risk than non-carriers (freq = 0.01, p-value = 0.015).