In addition, Sox17 and Sox4 respectively inhibit and enhance proliferation of colon carcinoma cells through physical interactions with β-catenin and TCF/LEF to modulate protein stability and transcriptional activity, and Sox6 interacts with β-catenin and HDAC1 to repress cyclin D1 promoter activity and proliferation in insulinoma cells [52], [53]. This evidence concerns the gene CCND1 and pancreatic insulinoma.