Additional genes that cause dominantly inherited forms of clinically typical ALS include the vesicle associated membrane protein (VAMP)-associated protein B (VAPB) (ALS8) [15], [16], the TAR DNA binding protein (TARDBP)[17] and the fused in sarcoma/translated in liposarcoma (FUS/TLS)[18], [19]. Here, VAPB is linked to sarcoma.