Given the fact that our analysis is cross-sectional in nature and that findings from clinical studies concerning the role of antibodies in the development of hypothyroidism after 131I therapy are conflicting (Ceccarelli et al. 2005; Chiovato et al. 1998; Mariotti et al. 1986), prospective data are needed to characterize the dynamic of radiation-related risk of hypothyroidism and to confirm its relation with ATPO. The gene discussed is ATP5PO; the disease is hypothyroidism.