BCL2 and infection: This indicates that apoptosis is essential for the reduction in CSF leukocyte counts as observed upon successful antibiotic therapy; if apoptosis is inhibited the CSF leukocyte numbers will stay up (percentages of apoptotic leukocytes in wt vs. Bcl-2 transgenic mice at 24 h after initiation of antibiotic therapy – when started at 18 hours after infection were: 13.7+/−1.5% vs. 3.7+/−1.5%).