To see if any novel pathological events occur in nNOS−/− mice treated with LT, we performed histopathological analyses on H&E-stained lung, heart, aorta, brain, kidney, spleen, liver and bone marrow obtained from knockout and control mice treated with LT for 7 h, 15 h, and a range of times between 23–36 h when different grades of malaise severity were noted. The gene discussed is NOS1; the disease is malaise.