A recent study by Agalliu et al. using 266 subjects in high-risk prostate cancer families also reported no disease-associated protein truncating BRCA2 mutations[30] Our study is unique in that we focused on pedigrees with strong linkage evidence near the BRCA2 gene region on chromosome 13q, and that all pedigrees met a very strict definition of high-risk. The gene discussed is BRCA2; the disease is prostate cancer.