About non significant correlation between plasma adiponectin levels and BMI in case group, it should be noted that in the most of previous studies [8,11,25,29] there were significant but weak correlation (r = -0.18 to -0.33) between them, So, in confirming Pliz et al opinion [11], it should be noted that the adiponectin levels may be more associated with blood lipid profile and insulin resistance instead of obesity. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.