Expression of IGFBP-5 were highest in the CIN stage II and III groups (1.0500 ± 0.0875), which were 4.94-fold higher than the relative expression levels of the normal group (0.2124 ± 0.0795) and 2.92-fold higher than those of the CC group (0.3600 ± 0.0575). This evidence concerns the gene IGFBP5 and cervical squamous intraepithelial neoplasia.