However, the sensitivity and specificity of serum HMGB1 was about 71% and 67% (cut-off value of 5 ng/ml) for the detection of cancer (EGC), and 70% and 64% (cut-off value of 4 ng/ml) for the detection of high risk lesions (IM or adenoma). The gene discussed is HMGB1; the disease is cancer.