TLR7 and systemic lupus erythematosus: As TLR7 has restricted cell distribution in humans (plasmacytoid DCs and B cells) and has been linked to lupus pathogenesis in mice [47-49], we next tested the ability of class R and B INH-ODNs to block TLR7-induced activation of macrophages, DCs, AM14 B cells, and primary mouse B cells.