RNPC3 and systemic lupus erythematosus: These findings have direct implications for the pathogenesis of systemic lupus erythematosus (SLE), a multisystemic disease in which autoantibodies to DNA- and RNA-containing autoantigens (for example, nucleosomes, Ku-autoantigen, Sm/RNP, or splicesosomes) are the immunologic hallmark of the disease [20-22].