PDCD4 and ductal breast carcinoma in situ: The expression of PDCD4 was located predominantly in nuclei in normal breast tissue (73% positivity in nucleus versus 13% positivity in cytoplasm) and FEA (93% versus 13%), whereas in DCIS and IDC positive cytoplasmic staining was observed in approximately half of the cases and nuclear staining was decreased (Table 3, Fig 3).