CD8A and neoplasm: In order to determine the E7-specific CD8+ T cell immune response in tumor-bearing mice treated with apigenin in combination with the E7-HSP70 DNA vaccine, we first challenged groups of C57BL/6 mice (5 per group) with TC-1 tumor cells and then treated them with apigenin alone, E7-HSP70 DNA vaccine alone or apigenin in combination with DNA vaccination.