The results presented show that ectopic sFRP1 expression in MDA-MB-231 tumor cells blocks the migratory ability and the proliferative potential of the tumor cells, both in vitro and in vivo, supporting the proposal that blockade of WNT signaling with sFRP1 might be a general approach to target not only breast, but also other types of cancer. The gene discussed is SFRP1; the disease is cancer.