3). Similarly, interaction of RCC cells with immobilized laminin was blocked distinctly by AEE788 or RAD001, and the combination therapy was superior than the single drug treatment (fig. 3). In contrast, binding of Caki-1 to fibronectin was not influenced neither by the single drug nor by the AEE-RAD combination. KTC-26 binding to fibronectin was blocked by AEE788 exclusively, whereas A498 binding was significantly reduced only when both compounds were used in combination (fig. 3). This evidence concerns the gene LAMB2 and renal cell carcinoma.