As for 16 base pair insertion polymorphism (rs59758982) in intron 3, Ressiniotis et al. [5] reported a significant difference in the p53 haplotype (rs1042522 and rs59758982) distribution between 140 British patients with POAG and 73 control subjects, and thus described that for individuals with 16 base pair insertion polymorphism an Arg72 was significantly more common in the patients than the controls. The gene discussed is TP53; the disease is open-angle glaucoma.