HGF demonstrated the most promising findings with the following evidence to support its association: (1) the significant p-values met the family-wide significance level based on Bonferroni correction (minimum p=0.0028 at rs3735520); (2) the association signal was consistent between mild to moderate and any myopia; (3) regardless of phenotype definition, SNPs in HGF showed some indication of association, even though it was not always from the same markers; and (4) the results were similar with the different phenotype definitions, SE and SP. The gene discussed is HGF; the disease is myopia.