The common sites of involvement are lung, lymphnode, pleura and peritoneum PUO is a frequent mode of presentation.[16] The risk factors proposed are advanced age, unemployment, reduced body mass index, decreased serum albumin, hemodialysis, Asian and Native American race, ischemic heart disease, smoking, illicit drug use and anemia.[17] One other study noted hypercalcemia and reversed Globulin/albumin ratio in these patients.[18] Treatment for those not planning for transplantation is short-course chemotherapy with a four-drug regimen. The gene discussed is ALB; the disease is anemia (phenotype).