Another controversy would be the endpoint of these studies, whether it is the prevention of death, regression of intraepithelial neoplasia or the decline in PSA both in men with intact prostate and in men with PSA relapse after radical prostatectomy.[22] One interesting study by Uzzo et al.,[73] showed that a high proportion of men at risk for prostate cancer self-initiated nutritional therapies in the form of various nutritional, vitamin and mineral supplements. This evidence concerns the gene KLK3 and intraepithelial neoplasia.