According to the reported data in the literature, the immunohistohemical profile of SVC is not as consistent regarding other tumor markers as for PSA, CK7, and CK20.[3, 5] Carcinoembryonic antigen (CEA) was expressed in most reported cases of SVC, including our case.[1, 5] Most well-differentiated papillary SVCs are CA-125 positive, while poorly differentiated SVCs, like our case, do not express this marker of müllerian duct differentiation.[3, 5] Thus müllerian duct cyst adenocarcinoma originated in seminal vesicle may be indistinguishable from conventional SVC. The gene discussed is KLK3; the disease is neoplasm.