The Rho/ROCK pathway has been significantly associated with invasion and metastasis of bladder cancer.[72] Reduced expression of the newly discovered metastasis suppressor gene RhoGDI2 correlates with increased invasive and metastatic activity in bladder carcinogenesis.[73] A study of bladder specimens demonstrated that decreased RhoGDI2 mRNA and protein expression were independent prognostic markers of disease relapse following radical cystectomy.[74]. The gene discussed is ARHGDIB; the disease is urinary bladder carcinoma.