They demonstrated that the presence of intratumoral neutrophils and low numbers of tumor-infiltrating CD57+ cells (positive in a subpopulation of the total NK cells) were significant prognostic factors of poor survival both in univariate and multivariate analyses, whereas intratumoral macrophages, CD4+, CD8+, CD20+ and CD56+ cells were not significant ones. This evidence concerns the gene CD4 and neoplasm.