In contrast to our findings, which show that mice lacking SLTs do not generate high-affinity Ab-responses, intranasal influenza infection of splenectomized LTα−/− mice reconstituted with wild-type (wt) stem cells, for instance, can initiate the formation of extra-lymphoid follicles within the lung, which support some degree of B cell maturation and Ab secretion [24],[26]. The gene discussed is LTA; the disease is influenza.