When comparing ChIP-on-chip results for Nipped-B and/or SMC1A binding sites in three different Drosophila cell types [48], homologs of 20 differentially expressed human genes in CdLS probands (FDR<0.05) were also found to be bound by NIPBL and cohesin (unpublished data). The gene discussed is NIPBL; the disease is Cornelia de Lange syndrome.