Because the role of CD8+ suppressor T cells has been postulated as a very important homeostatic mechanism in the gut mucosa [43], the infection site for hookworms, the demonstration of the role of CD8+ suppressor T cells in the regulation of gut immunity will be of importance not only to bring forward the role of these cells in the mucosal environment, but also to enhance the relevance of this effector population in the context of gastrointestinal parasitic infections. Here, CD8A is linked to parasitic infectious disease.