FL plus IL15-driven ACF/CD56+ cells have been found to progressively express an NK program, thereby lysing both NK and LAK-sensitive tumor cells and producing high levels of interferon-gamma (IFN-g), granulocyte/macrophage-colony stimulating factor (GM-CSF), tumor necrosis factor alpha (TNF-a) and IL-10, upon stimulation with IL-12 and IL-18. Here, IL18 is linked to neoplasm.