F2 and anaphylaxis: Clinical sequelae range from individuals with abnormal prothrombin time (PT), activated partial thromboplastin time (aPTT) and thrombin time (TT) who are asymptomatic and at risk for bleeding [18,25,28,29,31] to anaphylaxis [36], hemorrhage [19,27], or other critical adverse events [17,19,27,43,44].