The association between hemangiosarcoma and overexpression of acid ceramidase was reinforced in these analyses, but neither TSP-3, nor DLA-88, nor SMARCA1 showed differential expression according to breed in lymphoma and leukemia or in osteosarcoma, although those samples also appear to have different and unique sets of genes whose expression varies as a function of breed (T. Phang, K. Gavin, A. Sarver, and J. Modiano, unpublished data). Here, THBS3 is linked to leukemia.