PRNP and Creutzfeldt Jacob disease: In agreement with this, a recent study indicated that in CJD PrPSc glycoforms ratio significantly correlated with the genotype at codon 129 of the prion protein gene [49] Thus, strain-specific PrPSc glycosylation profiles could arise from a complex interaction between PrPC, PrPSc and the cell, and may indicate the cellular compartment in which the strain-specific formation of PrPSc occurs [29].