RAPGEF5 and T-cell acute lymphoblastic leukemia: Multiple RAP1 pathway genes also clustered with the LMO2-high group, including RAP1B, RAP1A and RAPGEF5. None are insertionally mutated in AKXD tumors, however, Rap1gds1 is insertionally mutated in tumor 98-031 and is the site of a recurrent chromosomal translocation in human T-ALL [30].