Strikingly, compared to WT littermate controls (Figure 5C), C57BL/6×C3H/HeN uPAR knock-out mice developed significantlymore severe carditis (Figure 5D), reflected by influx of greater numbers of leukocytes in more andlarger parts of cardiac tissue two weeks post infection (Figure 5E). The gene discussed is PLAUR; the disease is inflammation of heart layer.