IGF1 and colorectal cancer: There were also some observations, however, showing that IGF-I enhances the apoptotic response to anti-Fas antibody in colorectal cancer cells [13], potentiates tumour necrosis factor-α induced apoptosis in adipose-like cells [14], induces apoptosis in mouse fibroblast cells in the medium with low concentration of serum [15], and also in mouse skeletal muscle cells in the presence of tumour necrosis factor-α (TNF-α) [16].