PLAUR and AIDS dementia complex: The high levels of uPAR expression observed in the current study, during CNS inflammation induced by three distinct challenges (chronic neurodegeneration, acute neurotoxicity, and acute non-neurotoxic LPS), can perhaps explain the frequently reported elevations of suPAR in the CSF of patients with HIV dementia and other CNS conditions (Cinque et al.,2004; Garcia-Monco et al.,2002; Sporer et al.,2005; Winkler et al.,2002).