Even in a chronic disease, such as Alzheimer's disease (Walker et al.,2002), in which uPAR positive staining is colocalized with CD68-positive macrophages, it is not clear whether these are resident or infiltrating cells, because bone marrow-derived infiltrating macrophages have been reported to be selectively targeted to amyloid plaques in animal models of Alzheimer's disease (Simard et al.,2006). This evidence concerns the gene PLAUR and Alzheimer disease.