Other important genes include two breast cancer related genes, namely, the F2R gene, a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells (Boire et al. 2005); and PPAR binding protein, coactivator of ESR1 and overexpressed in breast cancer (Zhu et al. 1999). This evidence concerns the gene ESR1 and breast carcinoma.