In many human cancers, deregulation of mTOR signaling, which is caused by the loss of critical tumor suppressors (PTEN, TSC1/2, LKB1), somatic mutations or gene amplifications of PI3CA (p110 alpha subunit of PI3K) or activating mutations in AKT, ultimately leads to increased cell growth, cell survival, and suppression of autophagy [5]. The gene discussed is MTOR; the disease is cancer.