EGFR and breast carcinoma: In nude mice transplanted with human breast carcinoma, it was shown that rhEGF inhibited the growth of EGF receptor (EGFR)-positive MX-1 cells in a dose-dependent manner, whereas no changes were observed in the growth of cells of EGFR-negative MCF-7, Br-10 or T-61 after treatment with rhEGF.