The separation of the best and worst quartiles in the three IPI classes is comparable (Fig. 3) to the prediction success of the complete signature of Rosenwald et al. (2002) and classifies different patient quartiles better than the set proposed by Lossos et al. (2004; using LMO2, BCL6, FN1, CCND2, SCYA3 and BCL2 for overall survival in DLBCL). This evidence concerns the gene CCND2 and diffuse large B-cell lymphoma.