Increased expression of eukaryotic transcription factor 2 subunit 1 (EIF2S1 or EIF2A1), a member of the complex required to translate from transcript to protein, has been associated with several tumor types, with c-myc, an oncogene important in lung tumorigenesis, and with specific subtypes of lung cancer (e.g. Rosenwald et al. 1993; Lobo et al. 2000; Koessler et al. 2003; Clemens, 2004; Rosenwald, 2004). This evidence concerns the gene MYC and lung carcinoma.