P4HB and renal cell carcinoma: Other genes which we’ve identified as RCC related, but which have not previously been associated with any disease include ITPR2, which has roles in the calcium and phosphatidylinositol signaling pathways; glutaryl-Coenzyme A dehydrogenase (GCDH), which takes part in fatty acid metabolism,; 40S ribosomal protein S5 (RPS5), HIG1 (likely ortholog of hypoxia induced gene 1) and P4HB (proline 4-hydroxylase).