EGFR and lung adenocarcinoma: Reports on constitutive phosphorylation of STAT3 in some NSCLC cell lines (Song et al, 2003) and lung adenocarcinomas (Gao et al, 2007) are not in contrast with our observation because they reported relatively low percentages of strong phosphorylation and the STAT3 phosphorylation was mainly related to mutations in the EGFR kinase domain and IL-6 production.