APOE and colorectal carcinoma: However, recent studies have identified ApoE functions other than lipid metabolism such as DNA synthesis, β-catenin localisation, cell proliferation, antioxidant abilities, angiogenesis, and metastasis that may play a role in CRC (Vogel et al, 1994; Grocott et al, 2001; Niemi et al, 2002; Cedazo-Minguez et al, 2003).