The precursor of BNP is released during myocyte stress concerning the LV or the right ventricle: heart failure (when the ventricles are dilated, hypertrophic, or subject to increased wall tension), acute coronary syndromes, pulmonary disease (e.g., acute respiratory distress syndrome, lung disease with right heart failure), pulmonary embolism, high output states (e.g., sepsis, cirrhosis, hyperthyroidism), and atrial fibrillation [23].That is why the BNP level lacks specificity in critical care patients [24]. The gene discussed is NPPB; the disease is atrial fibrillation.