EGFR and neoplasm: The blockade of EGFR signalling in cancer cells not only determines the inhibition of cell proliferation but also has other effects that could be relevant for the clinical activity including induction of apoptosis; anti-angiogenesis through inhibition of angiogenic growth factor production; inhibition of invasion and metastasis; potentiation of anti-tumor activity of cytotoxic drugs and of radiotherapy [68].