Although transcription factors can be localised to nuclear inclusions formed by mutant huntingtin,12–14 it is unclear whether mutant huntingtin perturbs transcription by simply sequestering transcription factors in aggregates.15 Soluble mutant huntingtin may act to disrupt transcription factor binding to DNA.10, 11 Important work has revealed a role for wild-type huntingtin in HD where loss of function of huntingtin contributes to the severity of the disease by disrupting transcription of neuronal genes. Here, HTT is linked to Huntington disease.