CSF3 and non-Hodgkin lymphoma: A British National Lymphoma Investigation (BNLI) phase III study compared the efficacy and safety of two chemotherapy regimens (cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) or mitoxantrone, cyclophosphamide, etoposide, vincristine, bleomycin and prednisolone (PMitCEBO)) with or without granulocyte colony stimulating factor (G-CSF) in patients aged over 60 years with aggressive NHL [16].