ITK and hyperinsulinemic hypoglycemia, familial, 4: The aim of the study was to (1) define the transcriptome in unstimulated cells, (2) elucidate the influence of anti-CD3 and anti-CD3/CD28-stimulation and (3) to dissect which part of the observed alterations in Itk-deficiency is dependent on the calcineurin/NFAT pathway.