The t(X;17)(p11.2;q25) or TFE3-ASPL translocation RCC and alveolar soft part sarcoma (ASPS) contain the identical TFE3-ASPL fusion transcript; however, the t(X;17) translocation is consistently balanced (reciprocal) in the Xp11.2 translocation RCC and unbalanced in the ASPS [1]. This evidence concerns the gene TFE3 and renal cell carcinoma.