The classical cytogenetic profile of the tumor herein reported indicates the majority of the tumor cells with a translocation involving chromosome region Xp11.2/TFE3 and chromosome region 19q13.1, suggesting that the tumor is a Xp11.2 translocation RCC with a novel translocation involving chromosome 19 and a unilocular cystic and mural multinodular gross appearance. Here, TFE3 is linked to neoplasm.