A considerable number of these genes could be associated with anti-proliferative or tumor-suppressive processes, including apoptosis inducers Edg3 and Jip-2 [37,38], differentiation inducers Msln, Il5ra and Ebf2 [39-41], Prp19 (also known as Pso4) which is involved in DNA repair [42], Ragef3 which blocks chemotaxis induced by angiogenic factors [43] and Tyrp, which is expressed in poorly metastatic breast cancer and whose downregulation augments metastasis [44]. The gene discussed is S1PR3; the disease is breast cancer.