In the United States, dematiaceous fungi are the most common while Aspergillus species cause most cases reported in the Middle East.13 In conclusion, this study showed that the prevalence of AFS among patients with nasal polyps is 12.1%, and IgE level was higher in patients with AFS than those with chronic hyperplastic rhinosinusitis. The gene discussed is IGHE; the disease is nasal cavity polyp.